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Anti-sense nucleotides (ASOs) have demonstrated promise in lowering RNA foci and their deleterious effects and ASOs are under clinical trials for ALS treatment ( 3.2 Alzheimer's disease (AD) AD is a progressive ND characterized by neurofibrillary tangles produced by tau proteins as well as a buildup of amyloid plaques ( However, recent investigations of alternative therapies for AD have sparked interest in compounds with disease-modifying capability, one such molecule, a natural polyphenol, is curcumin, which has anti-inflammatory and antioxidant properties (Table 1)

Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1 and JAK2/STAT3 signaling pathway in rats

doi: 10.1155/2020/1308749 114 LiYXuQYangWWuTLuX

In general, the monoterpene diketone thymoquinone (2-isopropyl-5-methylbenzo-1,4-quinone) (TQ), present at levels of 30%48%, and the monocyclic monoterpene p -cymene, present at levels of 7%15%, are the 2 major components, although the phenolic monoterpene carvacrol (6%12%) is another important phytochemical (Figure 2)