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Obesity, Diabetes, and Leptin Resistance Promote Tau Pathology in a Mouse Model of Disease

Weight loss data from the ATTAIN trials showed an average of 12.4% body weight loss at the highest dose over 72 weeks meaningfully less than injectable Zepbound's 20%+ but with significantly better convenience

Conclusion Obesity pharmacotherapy in older adults should be encouraged as an adjunct to energy-restriction and physical activity, with an emphasis on resistance training