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But, doing that would get expensive

For example, low concentrations of HO promote cell survival by inhibiting the phosphatase PTEN and activating the PI3K/Akt pathway, while superoxide anions (O) produced by NOX 2 in macrophages induce pro-inflammatory cytokine expression via NF-B signaling to enhance antimicrobial immunity 18,19,20

Pathogenesis of allergic diseases and implications for therapeutic interventions

If testing negative, patients are submitted to germline testing, which includes the sequencing and the analysis of deletions and duplications in the appropriate MMR genes