glutathione and l cysteine L-Cysteine-glutathione disulfide Frontiers | Cysteine Depletion, a

Our study discovers a new role for ferroptosis in mediating motor neuron death in ALS, supporting the use of anti-ferroptotic therapeutic strategies, such as GPX4 pathway induction and upregulation, for ALS treatment

Our preclinical findings suggest that vitamin therapy could be a first-line therapy, particularly in patients with low serum B12 and folate levels and elevated serum homocysteine levels. The study provided excellent data in an area of research where there is limited information

Subsequent reperfusion triggers an abrupt overproduction of ROS, including hydrogen peroxide, superoxide anion, hydroxyl radical, singlet oxygen, hypochlorous acid, and nitric oxide 33 , amplifying oxidative stress and aggravating tissue injury