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Effective GVL is a key component of the curative potential of HSCT for hematologic malignancies, yet the biological basis for GVL remains poorly understood, thus limiting the ability to leverage this phenomenon for therapeutic benefit

Similarly, PAHs (e.g., benzo[a]pyrene and dibenz[a,h]anthracene) are metabolized by cytochrome P450 (CYP450) enzymes (e.g., CYP1A1) into highly reactive benzo[a]pyrene diol epoxides (BPDE)

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