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But "matters less" does not mean "does not matter at all." The initial 24 to 72 hours after injection represent a distinct pharmacokinetic phase where drug levels are rising rapidly

Ponirakis G, Abdul-Ghani MA, Jayyousi A, et al

Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis

Conversely, neutralizing angiopoietin-2 results in a reduction in blood vessel formation within adipose tissue, triggering pro-inflammatory and pro-fibrotic changes (331)