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10.1016/j.jpeds.2012.05.011 26

In 2 randomized, double-blind, placebo-controlled studies of adult chronic migraine sufferers, many study participants experienced a 50% reduction in headache days each month (8 to 9 days fewer headaches) through the use of BOTOX

For example, selonsertib (GS-4997) is a highly selective and potent ASK1 inhibitor with potential anti-inflammatory, anti-tumour, and anti-fibrotic activities 40