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Furthermore, the NOX inhibitor, diphenyleneiodonium, and the selective NOX1/4 isoform inhibitor, GKT137831, significantly inhibit erastin-induced ROS production, lipid ROS and cell death (106)

On the basis of these findings, the authors suggested that the principal mechanism of uncoupling is the oxidation of the zincthiolate center and subsequent release of zinc rather than the BH 4 oxidation process