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The oxidative stress-induced weakening of the fibrous cap covering the plaque, due to the degradation of extracellular matrix components by matrix metalloproteinases (MMPs), is a key factor in plaque instability [75]

In comparison to monocyte-derived macrophages from healthy volunteers, macrophages from patients with active CD were more susceptible to ferroptosis induced by in vitro exposure to H 2 O 2