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Synthesis efficiency depends on age (declining with aging), skin melanin content (darker skin reduces UVB absorption), latitude, and diet (fatty fish, fortified foods, supplements) ( 1.2.2 Vitamin D receptor and its signaling pathways The VDR, a nuclear receptor superfamily member expressed in intestines, kidneys, and immune cells, binds 1,25(OH)2D to regulate gene expression via vitamin D response elements (VDREs)

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VEGF - Vascular Endothelial Growth Factor Skin Structure of the skin The skin covering our body is considered one of the largest organs of our body