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Thereafter, it participates in the integrative stress response (ISR) and activates the transcription factor ATF4, which initiates the corresponding gene expression program

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Pandey et al., 2014)

Likewise, a study utilizing FDG-PET imaging of brain glucose metabolism revealed that PD is characterized by hypermetabolism in the putamen, pallidum, thalamic sensorimotor cortex, pons, and cerebellum, along with relative hypometabolism in the posterior temporal-parietal lobe, occipital lobe, and occasionally the frontal lobe, particularly in PD patients with cognitive impairment [36]