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In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

Kilburn-Watt E, Banati RB, Keay KA (2010) Altered thyroid hormones and behavioral change in a sub-population of rats following chronic constriction injury

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