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The primary role of mitochondria is the generation of ATP through the OXPHOS process

Although nanotechnology is increasingly used in cancer treatment, the application of NP-based therapy faces various issues, such as intrinsic immunogenicity and residual cytotoxicity (Shen et al., 2018)

In addition to urate transport inhibitors, xanthine oxidase inhibitors, as the most popular drug candidates, have attracted a lot of attention (Figure 2)

The lameness period (an indicator of joint pain and dysfunction) was significantly shorter in animals receiving AOD-9604 plus hyaluronic acid compared to other treatment groups