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However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists

Users should not expect the appetite reduction that comes with compounds like semaglutide or tirzepatide

The use of AOD 9604 and Tirzepatide should always be monitored to ensure safety and to align with post treatment goals

These populations often need higher or more frequent doses