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In animal models of depression, naringenin treatment has been shown to upregulate BDNF, SHH, GLI1, NK2 Homeobox 2 (NKX2.2), and Paired box protein Pax-6 (PAX6)

It is the free radicals that produce tyrosinase in the first place

Su X, Guo W, Yuan B, et al

Front Immunol 11:363 Jeng-Miller KW, Miller MA, Heier JS (2024) Ocular effects of MEK inhibitor therapy: literature review, clinical presentation, and best practices for mitigation