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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

What does the ALSFRS-R really measure

Lara-GuzmnOJGil-IzquierdoAMedinaSOsorioEAlvarez-QuinteroRZuluagaNet alOxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages

Moreover, we highlight recent therapeutic advances including the Food and Drug Administration (FDA) approval of resmetirom in 2024 and other promising agents currently in phase 2/3 trials providing a timely and translationally relevant overview that bridges current scientific evidence with emerging clinical applications in MASLD