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The actual question of the transfer of pathogenic A isoforms with post-translational modifications or mutations through the BBB still remains open

investigated the effect of statins as adjunctive therapy for tuberculosis in a retrospective cohort study and found no significant association between statin use and the risk of developing tuberculosis in diabetic patients (181)

Some other factors like illnesses, chronic colds, pollution, smoking and inflammatory conditions also lead to excessive usage of glutathione and hence, its depletion