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High doses may cause GI side effects

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Dynamics of extracellular vesicle uptake by mural granulosa cells in mice

Permeability of Metformin across an In Vitro Blood-Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs) Pharmaceutics

Drugs with molecular weights of 600 or greater are unlikely to penetrate milk in high concentrations.Typical examples of drugs with high molecular weights that are basically excluded from milk would include heparin (30,000), antibodies such as Remicade (144190), and insulin (6000)