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Key considerations for B12 intravenous dosing include: Initial dose: 1,000 mcg per infusion Frequency of administration: varies based on clinical need Monitoring of patient response to adjust dosing as necessary IV Infusion Methods and Duration B12 IV infusions are given slowly to avoid side effects

This activity was owing to increased expression of pyruvate carboxylase (Lee et al., 2013), or reduced expression of glutamate transporter-1 and K ir 4.1 K + channels, which are key regulators for the clearance of extracellular glutamate and maintenance of membrane potentials, respectively (Behrens et al., 2002

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