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For example, secondary RLS is often associated with high blood sugar related nerve damage or chronic vascular disease like deep vein thrombosis and arterial claudication (Gemignani 2007

However, the mechanism underlying how glutamine uptake and metabolism to GSH occur in CRPC and their effects on ferroptosis are unclear

There is a research demonstrating that the possible cytoprotective mechanisms of PA may be involved inhibition of the cyclooxygenase-2 pathway and the 5-lipoxygenase pathway to suppress inflammatory response and regulate the protective factor PPAR- expression in a chronic alcoholic liver damage model (Tian et al., 2021)

Ongoing studies targeting energy metabolism are providing novel insights and strategies for the treatment of autoimmune diseases, offering promising avenues for future therapeutic interventions