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Description

High free radical production occurred in primitive animal eukaryotic cells when they began using oxygen as a basis of their metabolism

10.1073/pnas.2000047117 P Natl Acad Sci U.S.A

The structural details are presented in Table 5

In parallel, glutaminase (GLS) inhibitors, including CB-839 (Telaglenastat), IACS-6274, and 6-diazo-5-oxo-L-norleucine (DON), are under clinical evaluation