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This heightens susceptibility to the toxic effects of iron overload, disrupting intestinal mucosal homeostasis and triggering local inflammation and cell death, ultimately precipitating the onset of gut-associated diseases ( Iron overload-related diseases rank among the most prevalent genetic disorders in humans, characterized pathologically by systemic iron accumulation resulting from excessive dietary iron absorption and iron-induced oxidative stress responses ( 3 Ferroptosis and inflammatory bowel disease The imbalance in ferroptosis regulation plays a key role in the pathogenesis of various diseases

J., van der Sluys Veer A., Verspaget H

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This shifts substrate preference toward lipids over glucose, increasing reliance on -oxidation and aggravating metabolic stress (van Gerwen et al., 2023)