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Pharmacodynamics of heroin and its metabolites Opioid receptors The pharmacology of the endogenous opioid system is exceedingly complex and the readers interested in a thorough discussion of this topic are referred to the many authoritative reviews published in recent years (e.g., [74,75,76]) The goal of this section is simply to highlight some aspects of opioid receptor pharmacology that are relevant to the issues discussed in the following sections

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