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Figure 1 In addition to energy failure, abnormally elevated levels of glutamate and increased activation of its receptors, result in intracellular calcium accumulation and increased production of reactive oxygen species (ROS) (Figure 1

5 In addition, high-intensity exercise also results in an increased production of lactic acid, which can further contribute to oxidative stress by causing a decrease in pH levels in the muscle tissues

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Supplementary Figure 14 Silencing of Rnd1 accelerates tumorigenesis, whereas ectopic expression of Rnd1 exerts the opposite effect