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Thus, following MCAO, GPx1 / mice had decreased microvascular perfusion and increased vascular permeability compared to wildtype mice

J Biol Chem (2001) 276:3098794

The expression of autophagy genes is increased in HepG2 ATP7B-KO and PHH WD cells To validate the copper-dependent gene regulation in HepG2 and HepG2 ATP7B-KO cells, both were cultured in RPMI medium, contrasting with the GSE107323 dataset, which used DMEM and RPMI medium, respectively

It is seen in this figure that mDia1 activates MAPKs including ERK1/2, p38 and c-JNK leading to the activation of their respective substrate, transcription factors which eventually enters the nucleus and transcribes downstream genes responsible for cell proliferation and apoptosis