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Knock out of ALCAT-1, an enzyme that promotes cardiolipin peroxidation protected against onset of cellular senescence and preserved mitochondrial function by reducing sensitivity to lipid oxidation

Ferroptosis can contribute to the manifestations of RILI, with IR inducing mitochondrial shrinkage, iron accumulation, ROS, and lipid peroxidation generation, and expression of ferroptosis-related genes [56, 71, 73]

Interestingly, iron was found to alter the balance between M1/M2 macrophage polarization, leading to macrophage-driven inflammation and fibrogenesis in nonalcoholic fatty liver disease (NAFLD) [64]

These findings have prompted further studies that look at how the extracellular matrix regulates the functionality of cells, with prior work highlighting the regulatory functions of the mechanical and signaling properties of ECM 59,157,158