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reported that FBXL4 deficiency could result in severe multi-system diseases, including lactic acidosis, cystic white matter disease, cardiomyopathy, arrhythmia, and immunodeficiency (141)

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4.4 Olfactory receptors in airway inflammatory regulation 4.4.1 Multicellular inflammatory microenvironment in airway inflammation pathogenesis The chronic inflammatory microenvironment in COPD emerges through coordinated interactions between immune cells and structural cells ( Figure 2 )