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Moreover, disease-induced alterations in Mn transporters and metabolism, and how these changes, in turn, exacerbate disease progression, remain largely unexplored

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue

However, both the Trx and Grx systems are not general mechanisms for maintaining protein thiols in the reduced state but preserve reduced thiols in specific proteins such as protein kinases, transcriptional regulators, and ribonucleotide reductase