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In the Macromolecules study, systematically swapping the amino acids on the hydrophobic face of the peptide changed its temperature- and pH-dependent gelling behavior, demonstrating that hydrophobic content controls assembly more than sheet propensity

Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

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At one month, realistic outcomes look like small but measurable shifts: a few pounds down if youve kept a sustained deficit, a slight waist reduction, steadier training, and improved daily activity