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This is significant as Schwann cells are the major glial cell type in the peripheral nervous system and play essential roles in nerve function, development, maintenance, and regeneration

doi: 10.1083/jcb.125.4.929

SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials

Primary research applications: In-vitro and pre-clinical models of skin regeneration, wound repair, hair-follicle biology, and tissue remodeling [3]