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However, these associations, primarily derived from observational studies, warrant cautious interpretation

This is because the sustained activation of PI3K-AKT pathway inhibits GSK3, which phosphorylates NRF2 and allows its recognition and ubiquitination by TrCP-CUL1 ubiquitin E3 ligase for degradation

Published receptor-binding and cellular-signaling studies have examined its potency and subtype selectivity relative to native melanocortins and to more selective analogs

This novel interdisciplinary practice demonstrates that it is possible to make the active ingredients in functional foods into edible anticancer prescriptions and accelerate their clinical application through collaboration across different fields