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Meanwhile, the reduction of beneficial metabolites such as SCFAs (as detailed in Section 3.2) further weakens the mucosal immune defense function, intensifying the activation of oxidative stress and inflammatory signaling pathways, thus forming a vicious cycle in the gut-lung axis and driving the progression of ALI/ARDS (Figure 1) (105)

Antiplatelet activity of a novel formula composed of malic acid, succinic acid and citric acid from Cornus officinalis fruit