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In addition to its involvement in synaptic plasticity and transmission, free ARA plays a crucial role in neuroinflammation through its conversion into various eicosanoids by cyclooxygenases, prostaglandin synthases, and lipoxygenases, the activities of which have been associated with neurodegenerative diseases ( via cPLA2 induction can be metabolized by COX or LOXs ( Amino acid metabolism and alzheimers disease Amino acids play an important role in the occurrence and development of AD

These molecules interact with receptors such as LFA-1, directly participating in immune cell activation and regulation, and play critical roles in the immunomodulatory functions of MenSCs

This allows us to analyze degenerative tinnitus as a phenomenon that progresses similarly to all kinds of peripheral tinnitus

& Tonelli, M