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Measurement of pulmonary function test (PFT) Pulmonary function testing (PFT) were performed in anesthetized mice after the insertion of a tracheal tube for mechanical breathing as previously described 67

Results We describe parenteral administration of OHCbl using a subcutaneous catheter together with a portable infusion pump in a home therapy setting in four pediatric patients with remethylation disorders, two patients with cblC, one patient with cblG, and one patient with cblE deficiency, in whom intramuscular injections were not or no longer feasible

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