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doi: 10.1016/j.freeradbiomed.2012.05.029

Some metabolic pathways were only mediated by one CYP isoform, such as the S -demethylation of 4MeS-NE-BP and 4MeS-P-BP via CYP2D6

Recent studies have increasingly recognized the heart-brain connection, demonstrating that even subclinical cardiac damage is a significant risk factor for dementia [71, 87,88,89]