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This is partly because they are missing a gene that codes for the production of glutathione

S -Nitroso- N -acetylpenicillamine (SNAP), a protein thiol-nitrosylating agent [40] previously reported to increase PDI S -nitrosylation [40], is also used in this study to explore the role of PDI S -denitrosylation in modulating erastin-induced ferroptosis in rat hepatocytes