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In addition, pooling data from different types of study designs, including case-controlled and cohort studies, may provide a higher number of studies compared with previous meta-analyses

Moreover, these compounds often induce only transient therapeutic effects, making precise dose control challenging

These significantly altered metabolites encompassed diverse classes, including Glycerophospholipids, Fatty Acyls, Prenol lipids, Steroids and steroid derivatives, Carboxylic acids and derivatives, Benzene and substituted derivatives, Phenylpropanoic acids, Benzopyrans, Organooxygen compounds, Glycerolipids, Flavonoids, Phenols, and Sphingolipids

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