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Current studies have shown that NRF2 deficiency enhances the susceptibility of PC12 cells to ferroptosis

Elliott JE, Keil AT, Mithani S, Gill JM, ONeil ME, Cohen AS, et al

doi: 10.1186/s12951-020-00700-8, 93

Based on our knowledge of the catalytic performance of chiral oligoEGs 1 (refs 26, 27, 28, 29, 30), the presence of the polyether backbone, the ether chain length (entries 6 and 7) and the acidity of phenolic protons (entry 2 versus entry 4) are crucial in achieving the catalytic activity and enantioselectivity