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Disclosures: Chun-Ming Hong: Nothing to Disclose, Chih-Horng Wu: Nothing to Disclose, Tung-Hung Su: Nothing to Disclose, Shih-Jer Hsu: Nothing to Disclose, Tai-Chung Tseng: Nothing to Disclose, Chen-Hua Liu: Nothing to Disclose, Hung-Chih Yang: Nothing to Disclose, Jia-Horng Kao: Nothing to Disclose, Pei-Jer Chen: Nothing to Disclose, Shang-Chin Huang: Nothing to Disclose, Chun Jen Liu: Nothing to Disclose 1793 RESVERATROL AND TANSHINONE IIA SYNERGIZE TO SUPPRESS HEPATOCELLULAR CARCINOMA BY MODULATING STROMAL CELLS TO REMODEL TUMOR MICROENVIRONMENT Jia Shi 1 Xuemei Zhang 1 Xiaona Lu 1 Shihan Yu 1 Wenlan Zheng 1 Hai Feng 1 Zhuo Yu 2 , 1 Shuguang hospital Affiliated to SHUTCM, 2 Shuguang Hospital Affiliated to Shanghai University of TCM Background: Hepatocellular carcinoma (HCC) is usually insensitive to immunotherapy due to the aggravated immunosuppressive statue in context of liver fibrosis