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10.1007/s12031-018-1027-0 J

Release 343 , 1330 (2022)

50 Increased neuronal iron disrupts neuromelanin-iron complexes, releasing toxic free iron and causing neuromelanin leakage, which further drives microglial M1 polarization and neurotoxin release

In the isoproterenol-induced chronic heart failure rat model, the left ventricular peak pressure (LVSP) and the maximum increase rate of left ventricular isovolumic systolic pressure (+dp/dtmax) are significantly increased in the total ginsenosides (TGS) and berberine combined group, while the left ventricular end-diastolic pressure (LVEDP), plasma BNP and cardiomyocyte Ca 2+ concentrations are significantly decreased