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The intrinsic pathway is triggered by diverse intracellular stresses, such as DNA damage, metabolic perturbations, or endoplasmic reticulum stress, leading to mitochondrial outer membrane permeabilization (MOMP)

S.SiassiF.QorbaniM.KhamoshianK.SotoudehG

Also, BDNF secreted by glial cells would activate TrkB signaling in neurons, through the MAPK/ERK and PLC/IP3 pathways that upregulate CREB, leading to increased neurogenesis and enhanced long-term potentiation (LTP), which were reduced by chronic alcohol consumption (Figure 1)