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In addition, heavy metals in foods like arsenic, lead and cadmium have been linked to several forms of cancer in multiple studies, including lung, kidney, bladder, stomach, brain, skin, liver, prostate, renal, breast, pancreatic and endometrial cancers

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Approved treatments for WD have serious drawbacks in a substantial cohort of patients 11 but the development of new therapeutic strategies is hampered by the poor understanding of the molecular mechanisms that can be exploited to normalize Cu homeostasis

The prepared FA-CMC-GNA NPs were internalized into A549 cells via folate receptor-mediated endocytosis and released gambogenic acid in response to GSH, resulting in a significant inhibitory effect on A549 cells