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Semaglutide's STEP 1 trial (1,961 subjects, 68 weeks) demonstrated 14.9% mean weight loss

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This metabolic shift is neuroprotective, reducing oxidative stress, inhibiting A plaque formation, attenuating neuroinflammation, and improving cognitive performance in animal models and early clinical investigations (Rusek et al., 2019

"The data and hypothesis are very intriguing, but much additional investigation is required to determine if this is a real cause-and-effect phenomenon," said Josh Miller, a professor of nutritional sciences at Rutgers University who was not involved with the study