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77 Fukudas team found that 9 of the 13 differentially expressed genes in allergic patients were mitochondria-related genes, including those producing cytochrome oxidases II and III, and NADH dehydrogenase

By its antioxidant properties, vitamin C neutralizes free radicals in the oral cavity, thereby reducing oxidative stress and decreasing the release of inflammatory mediators from gingival tissues ( 3.2.2 Research progress on vitamin E Vitamin E, as a fat-soluble antioxidant, serves as a important protective role in cell membranes through hindering lipid peroxidation, which makes it possibly useful for the prevention and treatment of periodontal health ( All in all, the mechanisms of action of vitamin E make it a possible therapeutic way for avoiding and treating periodontitis and related periodontal tissue health issues by its antioxidant and anti-inflammatory effects

Currently, evidence supporting lipoprotein involvement in pain regulation primarily stems from observational studies or preclinical experiments, with a lack of direct causal evidence from randomized controlled clinical trials

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