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Gigante B Article: EUROPEAN JOURNAL OF AGEING

(2019) 143:AB187

Analysis of clinical data clearly demonstrates that mitochondrial dysfunction accompanies disease progression in a substantial proportion of patients

Affinity chromatography is an important tool for selective biochemical separations This method uses a biologically-related binding agent as the stationary phase A literature survey is made of trends in this field over the past 50 years The principles, history, and applications of affinity chromatography are discussed Supports, coupling methods, and binding agents for this method are summarized Acknowledgements This work was funded, in part, by the University of Nebraska Research Council, the University of Nebraska-Lincoln College of Arts and Sciences, and the National Institutes of Health under grant R01 DK069629