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F.LiuQ.et al (2024)

demonstrated that individuals with IBD had significantly lower plasma TMAO concentrations compared to healthy controls Notably, patients with UC exhibited particularly low levels, markedly less than those observed in individuals with inactive disease (119, 120)

doi: 10.1016/j.jphotobiol.2016.12.036 30 HeZLiuZGongL

However, some people with TMAU as defined by the choline challenge test do not have any variants, either rare ones with total loss of function or common ones (associated with less extreme impairment) in this gene