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The escalation schedules that showed the best balance of efficacy and tolerability followed this general pattern: Weeks 1 through 4: 2mg once weekly

Curcumin formulations with enhanced bioavailability are thought to achieve therapeutic concentrations in plasma, which can reach dermal tissues to exert antiaging effects, particularly relevant for women experiencing estrogen decline [64]

[3] [51] Exposure of S

DUBs also contribute, as USP28 stabilizes c-Myc to suppress ATM/ATR checkpoints [56], while OTUD5 deubiquitinates Akt to inhibit mTOR/NF-B in cervical cancer [57]