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These findings suggest that the influence of estrogen on the inflammatory response induced by CIH may be concentration-dependent, warranting further investigation to determine whether similar concentration-dependent effects of estrogen are observed in other tissues

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Conclusions Our findings reveal a growing trend toward digital integration in rare disease trials to support decentralized, scalable, and patient-centered research models

Furthermore, our single-cell mass cytometry approach was limited to ~40 proteins, capping the number of metabolic pathways we could interrogate simultaneously