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Vigilance during administration and awareness of these potential risks are essential for safe treatment

Brain 146 , 29572974 (2023)

Some people with severe glutathione synthetase deficiency also develop recurrent bacterial infections

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth