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Theres no guarantee that tranexamic acid will work for you - and generally it has been thought of as a last resort of sorts for treating the melasma cases that are resistant to laser therapy and other medications, because it does have potential side effects, whereas laser therapy does not

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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear